Advertisement

Nonsurgical Approaches to the Aging Neck

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Advances in Cosmetic Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. ASDS Survey on Dermatologic Procedures.
        (Available at:) (Accessed February 5, 2020)
      2. Nicholas MN HS, Kaminer MS, Dover JS. Non-Invasive Techniques. In: Slavin SLaS, ed. Neck Rejuvenation: Surgical and Non-Surgical Techniques: Thieme; 2021:In Press.

        • Farage M.A.
        • Miller K.W.
        • Elsner P.
        • et al.
        Intrinsic and extrinsic factors in skin ageing: a review.
        Int J Cosmet Sci. 2008; 30: 87-95
        • Flament F.
        • Bazin R.
        • Laquieze S.
        • et al.
        Effect of the sun on visible clinical signs of aging in Caucasian skin.
        Clin Cosmet Investig Dermatol. 2013; 6: 221-232
        • Fisher G.J.
        • Varani J.
        • Voorhees J.J.
        Looking older: fibroblast collapse and therapeutic implications.
        Arch Dermatol. 2008; 144: 666-672
        • Mashkevich G.
        • Wang J.
        • Rawnsley J.
        • et al.
        The utility of ultrasound in the evaluation of submental fullness in aging necks.
        Arch Facial Plast Surg. 2009; 11: 240-245
        • Kenkel J.M.
        • Jones D.H.
        • Fagien S.
        • et al.
        Anatomy of the Cervicomental Region: Insights From an Anatomy Laboratory and Roundtable Discussion.
        Dermatol Surg. 2016; 42: S282-S287
        • Ellenbogen R.
        • Karlin J.V.
        Visual criteria for success in restoring the youthful neck.
        Plast Reconstr Surg. 1980; 66: 826-837
        • Ortonne J.P.
        The effects of ultraviolet exposure on skin melanin pigmentation.
        J Int Med Res. 1990; 18: 8c-17c
        • Kligman A.
        The future of cosmeceuticals: an interview with Albert Kligman, MD, PhD. Interview by Zoe Diana Draelos.
        Dermatol Surg. 2005; 31: 890-891
        • Brandt F.S.
        • Cazzaniga A.
        • Hann M.
        Cosmeceuticals: Current Trends and Market Analysis.
        Semin Cutan Med Surg. 2011; 30: 141-143
        • Boen M.
        • Alhaddad M.
        • Wu D.C.
        • et al.
        A prospective double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the aging neck.
        J Clin Aesthet Dermatol. 2020; 13: 13-18
        • Saxena S.J.
        • Duque D.
        • Schirripa M.J.
        Assessment of a comprehensive anti-aging neck cream.
        J Drugs Dermatol. 2015; 14: 997-1002
        • Schlessinger J.
        • Green B.
        • Edison B.L.
        • et al.
        A Firming Neck Cream Containing N-Acetyl Glucosamine Significantly Improves Signs of Aging on the Challenging Neck and Décolletage.
        J Drugs Dermatol. 2016; 15: 47-52
        • Chajchir I.
        • Modi P.
        • Chajchir A.
        Novel topical BoNTA (CosmeTox, toxin type A) cream used to treat hyperfunctional wrinkles of the face, mouth, and neck.
        Aesthetic Plast Surg. 2008; 32 ([discussion: 723]): 715-722
        • Cook K.K.
        • Cook Jr., W.R.
        Chemical peel of nonfacial skin using glycolic acid gel augmented with TCA and neutralized based on visual staging.
        Dermatol Surg. 2000; 26: 994-999
        • Fulton J.E.
        • Rahimi A.D.
        • Helton P.
        • et al.
        Neck rejuvenation by combining Jessner/TCA peel, dermasanding, and CO2 laser resurfacing.
        Dermatol Surg. 1999; 25: 745-750
        • Rendon M.I.
        • Berson D.S.
        • Cohen J.L.
        • et al.
        Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing.
        J Clin Aesthet Dermatol. 2010; 3: 32-43
        • Rusciani A.
        • Motta A.
        • Fino P.
        • et al.
        Treatment of Poikiloderma of Civatte Using Intense Pulsed Light Source: 7 Years of Experience.
        Dermatol Surg. 2008; 34: 314-319
        • Weiss R.A.
        • Goldman M.P.
        • Weiss M.A.
        Treatment of poikiloderma of Civatte with an intense pulsed light source.
        Dermatol Surg. 2000; 26 ([discussion: 828]): 823-827
        • Bernstein E.F.
        • Schomacker K.
        • Paranjape A.
        • et al.
        Treatment of poikiloderma of Civatte using a redesigned pulsed dye laser with a 15mmdiameter treatment spot.
        Lasers Surg Med. 2019; 51: 54-58
        • Batta K.
        • Hindson C.
        • Cotterill J.A.
        • et al.
        Treatment of poikiloderma of Civatte with the potassium titanyl phosphate (KTP) laser.
        Br J Dermatol. 1999; 140: 1191-1192
        • Behroozan D.S.
        • Goldberg L.H.
        • Glaich A.S.
        • et al.
        Fractional Photothermolysis for Treatment of Poikiloderma of Civatte.
        Dermatol Surg. 2006; 32: 298-301
        • Bencini P.L.
        • Tourlaki A.
        • Galimberti M.
        • et al.
        Non-ablative fractionated laser skin resurfacing for the treatment of aged neck skin.
        J Dermatol Treat. 2015; 26: 252-256
        • Luebberding S.
        • Alexiades-Armenakas M.R.
        Fractional, nonablative Q-switched 1,064-nm neodymium YAG laser to rejuvenate photoaged skin: a pilot case series.
        J Drugs Dermatol. 2012; 11: 1300-1304
        • Jones D.
        • Carruthers A.
        • Hardas B.
        • et al.
        Development and Validation of a Photonumeric Scale for Evaluation of Transverse Neck Lines.
        Dermatol Surg. 2016; 42: S235-S242
        • Lee J.H.
        • Park Y.G.
        • Park E.S.
        A prospective observational study of the effectiveness and safety of botulinum toxin in the horizontal neck lines.
        Aesthetic Plast Surg. 2018; 42: 1370-1378
        • Jeon H.
        • Kim T.
        • Kim H.
        • et al.
        Multimodal approach for treating horizontal neck wrinkles using intensity focused ultrasound, cohesive polydensified matrix hyaluronic acid, and incobotulinumtoxinA.
        Dermatol Surg. 2018; 44: 421-431
        • Tseng F.
        • Yu H.
        Treatment of Horizontal Neck Wrinkles with Hyaluronic Acid Filler: A Retrospective Case Series.
        Plast Reconstr Surg Glob Open. 2019; 7: e2366
        • Lee S.K.
        • Kim H.S.
        Correction of horizontal neck lines: Our preliminary experience with hyaluronic acid fillers.
        J Cosmet Dermatol. 2018; 17: 590-595
        • Minokadeh A.
        • Black J.M.
        • Jones D.H.
        Effacement of Transverse Neck Lines With VYC-15L and Cohesive Polydensified Matrix Hyaluronic Acid.
        Dermatol Surg. 2018; 44: S53-S56
        • Chao Y.Y.
        • Chiu H.H.
        • Howell D.J.
        A Novel Injection Technique for Horizontal Neck Lines Correction Using Calcium Hydroxylapatite.
        Dermatol Surg. 2011; 37: 1542-1545
        • Casabona G.
        • Nogueira Teixeira D.
        Microfocused ultrasound in combination with diluted calcium hydroxylapatite for improving skin laxity and the appearance of lines in the neck and decolletage.
        J Cosmet Dermatol. 2018; 17: 66-72
        • Oram Y.
        • Akkaya A.D.
        Neck Rejuvenation with Fractional CO2 Laser: Long-term Results.
        J Clin Aesthet Dermatol. 2014; 7: 23-29
        • Vanaman M.
        • Fabi S.G.
        • Cox S.E.
        Neck Rejuvenation Using a Combination Approach: Our Experience and a Review of the Literature.
        Dermatol Surg. 2016; 42: S94-S100
        • Kerscher M.
        • Nurrisyanti A.T.
        • Eiben-Nielson C.
        • et al.
        Skin physiology and safety of microfocused ultrasound with visualization for improving skin laxity.
        Clin Cosmet Investig Dermatol. 2019; 12: 71-79
        • Geister T.L.
        • Bleßmann-Gurk B.
        • Rzany B.
        • et al.
        Validated Assessment Scale for Platysmal Bands.
        Dermatol Surg. 2013; 39: 1217-1225
        • Brandt F.S.
        • Bellman B.
        Cosmetic Use of Botulinum A Exotoxin for the Aging Neck.
        Dermatol Surg. 1998; 24: 1232-1234
        • Matarasso A.
        • Matarasso S.L.
        • Brandt F.S.
        • et al.
        Botulinum A exotoxin for the management of platysma bands.
        Plast Reconstr Surg. 1999; 103 ([discussion: 653–5]): 645-652
        • Ascher B.
        • Talarico S.
        • Cassuto D.
        • et al.
        International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit)--Part II: Wrinkles on the middle and lower face, neck and chest.
        J Eur Acad Dermatol Venereol. 2010; 24: 1285-1295
        • Chen D.L.
        • Cohen J.L.
        Botulinum Toxin-A chemical denervation for platysmal bands: maximal dosing considerations.
        J Drugs Dermatol. 2015; 14: 931
        • Sugrue C.M.
        • Kelly J.L.
        • McInerney N.
        Botulinum toxin treatment for mild to moderate platysma bands: a systematic review of efficacy, safety, and injection technique.
        Aesthet Surg J. 2018; 39: 201-206
        • Levy P.M.
        The ‘Nefertiti lift’: A new technique for specific re-contouring of the jawline.
        J Cosmet Laser Ther. 2007; 9: 249-252
        • de Almeida A.R.T.
        • Romiti A.
        • Carruthers J.D.A.
        The Facial Platysma and Its Underappreciated Role in Lower Face Dynamics and Contour.
        Dermatol Surg. 2017; 43: 1042-1049
        • Awaida C.J.
        • Jabbour S.F.
        • Rayess Y.A.
        • et al.
        Evaluation of the microbotox technique: an algorithmic approach for lower face and neck rejuvenation and a crossover clinical trial.
        Plast Reconstr Surg. 2018; 142: 640-649
        • Leal Silva H.G.
        Facial laxity rating scale validation study.
        Dermatol Surg. 2016; 42: 1370-1379
        • Yutskovskaya Y.A.
        • Kogan E.A.
        Improved neocollagenesis and skin mechanical properties after injection of diluted calcium hydroxylapatite in the neck and decolletage:a pilot study.
        J Drugs Dermatol. 2017; 16: 68-74
        • de Almeida A.T.
        • Figueredo V.
        • da Cunha A.L.G.
        • et al.
        Consensus recommendations for the use of hyperdiluted calcium hydroxyapatite (radiesse) as a face and body biostimulatory agent.
        Plast Reconstr Surg Glob Open. 2019; 7: e2160
        • Mazzuco R.
        • Hexsel D.
        Poly-l-lactic acid for neck and chest rejuvenation.
        Dermatol Surg. 2009; 35: 1228-1237
        • Alhaddad M.
        • Wu D.C.
        • Bolton J.
        • et al.
        A randomized, split-face, evaluator-blind clinical trial comparing monopolar radiofrequency versus microfocused ultrasound with visualization for lifting and tightening of the face and upper neck.
        Dermatol Surg. 2019; 45: 131-139
        • Alexiades M.
        • Berube D.
        Randomized, blinded, 3-arm clinical trial assessing optimal temperature and duration for treatment with minimally invasive fractional radiofrequency.
        Dermatol Surg. 2015; 41: 623-632
        • Serdar Z.A.
        • Tatlıparmak A.
        Comparison of efficacy and safety of fractional radiofrequency and fractional Er:YAG laser in facial and neck wrinkles: Six-year experience with 333 patients.
        Dermatol Ther. 2019; 32: e13054
        • Alessa D.
        • Bloom J.D.
        Microneedling options for skin rejuvenation, including non-temperature-controlled fractional microneedle radiofrequency treatments.
        Facial Plast Surg Clin North Am. 2020; 28: 1-7
        • Tan M.G.
        • Jo C.E.
        • Chapas A.
        • et al.
        Radiofrequency microneedling: a comprehensive and critical review.
        Dermatol Surg. 2021; 47: 755-761
      3. American Society for Dermatologic Surgery 2019 Consumer Survey on Cosmetic Dermatologic Procedures.
        (Available at:) (Accessed April 16, 2020)
        • Jones D.H.
        • Kenkel J.M.
        • Fagien S.
        • et al.
        Proper Technique for Administration of ATX-101 (Deoxycholic Acid Injection): insights from an injection practicum and roundtable discussion.
        Dermatol Surg. 2016; 42: S275-S281
        • Ascher B.
        • Fellmann J.
        • Monheit G.
        ATX-101 (deoxycholic acid injection) for reduction of submental fat.
        Expert Rev Clin Pharmacol. 2016; 9: 1131-1143
        • Hogan S.
        • Kandula P.
        • Callaghan D.J.
        • et al.
        Submental fat contouring: a comparison of deoxycholic acid, cryolipolysis, and liposuction.
        Adv Cosmet Surg. 2019; 2: 75-87
        • Cunha K.S.
        • Lima F.
        • Cardoso R.M.
        Efficacy and safety of injectable deoxycholic acid for submental fat reduction: a systematic review and meta-analysis of randomized controlled trials.
        Expert Rev Clin Pharmacol. 2021; 14: 383-397
        • Dayan S.H.
        • Schlessinger J.
        • Beer K.
        • et al.
        Efficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials.
        Aesthet Surg J. 2018; 38: 998-1010
        • Humphrey S.
        • Sykes J.
        • Kantor J.
        • et al.
        ATX-101 for reduction of submental fat: A phase III randomized controlled trial.
        J Am Acad Dermatol. 2016; 75: 788-797.e7
        • Shridharani S.M.
        Real-World Experience With 100 Consecutive Patients Undergoing Neck Contouring With ATX-101 (Deoxycholic Acid): An Updated Report With A 2-Year Analysis.
        Dermatol Surg. 2019; 45: 1285-1293
        • Shridharani S.M.
        Improvement in Jowl Fat following ATX-101 treatment: results from a single-site study.
        Plast Reconstr Surg. 2020; 145: 929-935
        • Teller C.F.
        • Chiu A.
        • Chesnut C.D.
        • et al.
        Best Clinical Practices with ATX-101 for submental fat reduction: patient-related factors and physician considerations.
        Plast Reconstr Surg Glob Open. 2021; 9: e3668
        • Bernstein E.F.
        • Bloom J.D.
        Safety and efficacy of bilateral submental cryolipolysis with quantified 3-dimensional imaging of fat reduction and skin tightening.
        JAMA Facial Plast Surg. 2017; 19: 350-357
        • Kilmer S.L.
        • Burns A.J.
        • Zelickson B.D.
        Safety and efficacy of cryolipolysis for non-invasive reduction of submental fat.
        Lasers Surg Med. 2016; 48: 3-13
        • Gregory A.
        • Humphrey S.
        • Varas G.
        • et al.
        Atypical Pain Developing Subsequent to Cryolipolysis for Noninvasive Reduction of Submental Fat.
        Dermatol Surg. 2019; 45: 487-489
        • Shah G.M.
        • Greenberg J.N.
        • Tanzi E.L.
        • et al.
        Noninvasive approach to treatment of submental fullness.
        Semin Cutan Med Surg. 2017; 36: 164-169
        • Leclère F.M.
        • Vogt P.M.
        • Moreno-Moraga J.
        • et al.
        Laser-assisted lipolysis for neck and submental remodeling in Rohrich type IV patients: Fact or fiction?.
        J Cosmet Laser Ther. 2015; 17: 31-36
        • Leclère F.M.
        • Moreno-Moraga J.
        • Alcolea J.M.
        • et al.
        Laser assisted lipolysis for neck and submental remodeling in Rohrich type I to III aging neck: A prospective study in 30 patients.
        J Cosmet Laser Ther. 2014; 16: 284-289
        • Sarnoff D.S.
        Evaluation of the safety and efficacy of a novel 1440nm Nd:YAG laser for neck contouring and skin tightening without liposuction.
        J Drugs Dermatol. 2013; 12: 1382-1388
        • Valizadeh N.
        • Jalaly N.Y.
        • Zarghampour M.
        • et al.
        Evaluation of safety and efficacy of 980-nm diode laser-assisted lipolysis versus traditional liposuction for submental rejuvenation: A randomized clinical trial.
        J Cosmet Laser Ther. 2016; 18: 41-45
        • Park J.-H.
        • Kim J.-I.
        • Park H.J.
        • et al.
        Evaluation of safety and efficacy of noninvasive radiofrequency technology for submental rejuvenation.
        Lasers Med Sci. 2016; 31: 1599-1605
        • Alster T.S.
        • Tanzi E.
        Improvement of neck and cheek laxity with a nonablative radiofrequency device: a lifting experience.
        Dermatol Surg. 2004; 30 ([discussion: 507]): 503-507
        • Fritz M.
        • Counters J.T.
        • Zelickson B.D.
        Radiofrequency treatment for middle and lower face laxity.
        Arch Facial Plast Surg. 2004; 6: 370-373
        • Angra K.
        • Alhaddad M.
        • Boen M.
        • et al.
        Prospective clinical trial of the latest generation of noninvasive monopolar radiofrequency for the treatment of facial and upper neck skin laxity.
        Dermatol Surg. 2021; 47: 762-766
        • Kerscher M.
        • Nurrisyanti A.T.
        • Eiben-Nielson C.
        • et al.
        Clinical and Biophysical outcomes of combining microfocused ultrasound with visualization and calcium hydroxylapatite filler for facial treatment.
        Dermatol Ther (Heidelb). 2019; 9: 135-142
        • Werschler W.P.
        • Werschler P.S.
        Long-term efficacy of micro-focused ultrasound with visualization for lifting and tightening lax facial and neck skin using a customized vectoring treatment method.
        J Clin Aesthet Dermatol. 2016; 9: 27-33
        • Oni G.
        • Hoxworth R.
        • Teotia S.
        • et al.
        Evaluation of a microfocused ultrasound system for improving skin laxity and tightening in the lower face.
        Aesthet Surg J. 2014; 34: 1099-1110
        • Fabi S.G.
        • Joseph J.
        • Sevi J.
        • et al.
        Optimizing Patient Outcomes by Customizing Treatment With Microfocused Ultrasound With Visualization: Gold Standard Consensus Guidelines from an Expert Panel.
        J Drugs Dermatol. 2019; 18: 426-432
      4. Consensus Recommendations for 4th Generation Non-Microneedling Monopolar Radiofrequency for Skin Tightening: A Delphi Consensus Panel.
        J Drugs Dermatol. 2020; 19: 20-26
        • Rzany B.
        • Griffiths T.
        • Walker P.
        • et al.
        Reduction of unwanted submental fat with ATX-101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase III, randomized, placebo-controlled study.
        Br J Dermatol. 2014; 170: 445-453
        • Jones D.H.
        • Carruthers J.
        • Joseph J.H.
        • et al.
        REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction.
        Dermatol Surg. 2016; 42: 38-49
        • Shridharani S.M.
        Early Experience in 100 Consecutive Patients With Injection Adipocytolysis for Neck Contouring With ATX-101 (Deoxycholic Acid).
        Dermatol Surg. 2017; 43: 950-958
        • Beer K.
        • Weinkle S.H.
        • Cox S.E.
        • et al.
        ATX-101 (Deoxycholic Acid Injection) for Reduction of Submental Fat: Results From a 12-Month Open-Label Study.
        J Drugs Dermatol. 2019; 18: 870-877
        • Behr K.
        • Kavali C.M.
        • Munavalli G.
        • et al.
        ATX-101 (Deoxycholic Acid Injection) Leads to Clinically Meaningful Improvement in Submental Fat: Final Data From CONTOUR.
        Dermatol Surg. 2020; 46: 639-645
        • Glogau R.G.
        • Glaser D.A.
        • Callender V.D.
        • et al.
        A Double-Blind, Placebo-Controlled, Phase 3b Study of ATX-101 for Reduction of Mild or Extreme Submental Fat.
        Dermatol Surg. 2019; 45: 1531-1541
        • Shome D.
        • Khare S.
        • Kapoor R.
        The use of deoxycholic acid for the clinical reduction of excess submental fat in Indian patients.
        J Drugs Dermatol. 2019; 18: 266-272
        • Jain M.
        • Savage N.E.
        • Spiteri K.
        • et al.
        A 3-dimensional quantitative analysis of volume loss following submental cryolipolysis.
        Aesthet Surg J. 2020; 40: 123-132
        • de Gusmao P.R.
        • Canella C.
        • de Gusmao B.R.
        • et al.
        Cryolipolysis for local fat reduction in adults from Brazil: A single-arm intervention study.
        J Cosmet Dermatol. 2020; 19: 2898-2905
        • Suh D.H.
        • Park J.H.
        • Jung H.K.
        • et al.
        Cryolipolysis for submental fat reduction in Asians.
        J Cosmet Laser Ther. 2018; 20: 24-27
        • Leal Silva H.
        • Carmona Hernandez E.
        • Grijalva Vazquez M.
        • et al.
        Noninvasive submental fat reduction using colder cryolipolysis.
        J Cosmet Dermatol. 2017; 16: 460-465