Review Article| Volume 5, ISSUE 1, P63-77, May 2022

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The Ultralift

Ultrasound and Energy-Based Facelifting
  • Richard D. Gentile
    821 Kentwood Suite C, Youngstown, OH 44512.
    Facial Plastic Surgery, Gentile Facial Plastic Surgery & Aesthetic Laser Center, 821 Kentwood Suite C, Youngstown, OH 44512, USA

    Facial Plastic Surgery, Cleveland Clinic, Akron General Hospital, Akron, OH, USA
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      1. Population of the U.S. by sex and age 2017 Statistic of the United States by sex and age 2017 There were about 11.35 million males between the ages of 20 and 24-years-old in the United States in

        • Arnoczky S.P.
        • Aksan A.
        Thermal modification of connective tissues: basic science considerations and clinical implications.
        J Am Acad Orthop Surg. 2000; 8: 305-313
        • Ross E.V.
        • Yashar S.S.
        • Naseef G.S.
        • et al.
        A pilot study of in vivo immediate tissue contraction with CO2 skin laser resurfacing in a live farm pig.
        Dermatol Surg. 1999; 25: 851-856
        • Le Louis M.
        • Flandin F.
        • Herbage D.
        • et al.
        Influence of collagen denaturation on the chemorheological properties of skin, assessed by differential scanning calorimetry and hydrothermal isometric tension measurement.
        Biochim Biophys Acta. 1982; 717: 295-300
        • Hsu T.S.
        • Kaminer M.S.
        The use of nonablative radiofrequency technology to tighten the lower face and neck.
        Semin Cutan Med Surg. 2003; 22: 115-123
        • Barton J.K.1
        • Rollins A.
        • Yazdanfar S.
        • et al.
        Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modelling.
        Phys Med Biol. 2001; 46: 1665-1678
        • Gentile R.D.
        Smartlifting™-a technological innovation for facial rejuvenation. Cynosure white paper available.
        (Available at:) (Accessed 4-24-4014)
        • Gentile R.D.
        Laserfacialsculpting™ minimally invasive techniques for facial rejuvenation utilizing the smartlipo™ Nd:YAG laser February 1, 2010.
        (Available at) (Accessed 4-27-2014)
        • Gentile R.D.
        SmartLifting™ fiber laser-assisted facial rejuvenation techniques.
        Facial Plast Surg Clin North Am. 2011; 19: 371-387
        • Gentile R.D.
        Laser-assisted neck-lift: high-tech contouring and tightening.
        Facial Plast Surg. 2011; 27: 331-345
      2. Dinh V., (2006). Low-power laser therapy. Biomedical photonics handbook. CRC Press, pp. 48-1-48-25.

        • Lubart R.
        • Friedmann H.
        • Lavie R.
        • et al.
        A reasonable mechanism for visible light-induced skin rejuvenation.
        Lasers Med Sci. 2007; 22: 1-3
        • Pereira A.N.
        • Eduardo C.P.
        • Matson E.
        • et al.
        Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts.
        Lasers Surg Med. 2007; 31: 263-267
        • Rattan S.I.
        Repeated mild heat shock delays ageing in cultured human skin fibroblasts.
        Biochem Mol Biol Int. 1998; 45: 753-759
        • Watanabe S.
        Basics of laser application to dermatology.
        Arch Dermatol Res. 2008; 300: S21-S30
        • Snoeckx L.H.
        • E H.
        • Cornelussen R.N.
        • et al.
        Heat shock proteins and cardiovascular pathophysiology.
        Physiol Rev. 2007; 81: 1461-1497
        • Ebling Rook
        • Wilkinson
        Textbook of dermatology.
        Blackwell Scientific Publcations, 1992
        • Geronemus R.G.
        Fractional photothermolysis: current and future applications.
        Lasers Surg Med. 2006; 38: 169-176
        • Gilchrest B.A.
        A review of skin ageing and its medical therapy.
        Br J Dermatol. 2007; 135: 867-875
        • Sadick N.S.
        Update on non-ablative light therapy for rejuvenation: a review.
        Lasers Surg Med. 2006; 32: 120-128
        • Goldberg D.J.
        Lasers for facial rejuvenation.
        Am J Clin Deatology. 2006; 4: 225-323
        • Capon A.
        • Mordon S.
        Can thermal lasers promote skin wound healing?.
        Am J Clin Dermatol. 2006; 4: 1-12
        • Stadelmann W.K.
        • Digenis A.G.
        • Tobin G.R.
        Physiology and healing dynamics of chronic cutaneous wounds.
        Am J Surg. 2006; 176: 26S-38S
        • Bowers W.
        • Blaha M.
        • Alkhyyat A.
        • et al.
        Artificial human skin: cytokine, prostaglandin, HSP70 and histological responses to heat exposure.
        J Dermatol Sci. 2007; 20: 172-182
        • Kovalchin J.T.
        • Wang R.
        • Wagh M.S.
        • et al.
        In vivo delivery of heat shock protein 70 accelerates wound healing by up- regulating macrophage-mediated phagocytosis.
        Wound Repair Regen. 2006; 14: 129-137
        • Marshall H.
        • Kind C.N.
        Detection and cellular localization of stress-induced 72 kD heat shock protein in cultured Swiss 3T3 mouse fibroblasts.
        Toxicol In Vitro. 2007; 8: 545-548
        • Ohtsuka K.
        • Laszlo A.
        The relationship between hsp 70 localization and heat resistance.
        Exp Cell Res. 2007; 202: 507-518
        • Souil E.
        • Capon A.
        • Mordon S.
        • et al.
        Treatment with 815-nm diode laser induces long-lasting expression of 72-kDa heat shock protein in normal rat skin.
        Br J Dermatol. 2001; 144: 260-266
        • Naitoh M.
        • Hosokawa N.
        • Kubota H.
        • et al.
        Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid.
        Biochem Biophys Res Commun. 2001; 280: 1316-1322
        • Tasab M.
        • Jenkinson L.
        • Bulleid N.J.
        Sequence-specific recognition of collagen triple helices by the collagen-specific molecular chaperone HSP47.
        J Biol Chem. 2002; 277: 35007-35012
        • Verrico A.K.
        • Haylett A.K.
        • Moore J.V.
        In vivo expression of the collagen- related heat shock protein HSP47, following hyperthermia or photodynamic therapy.
        Lasers Med Sci. 2001; 16: 192-198
        • Verrico A.K.
        • Moore J.V.
        Expression of the collagen-related heat shock protein HSP47 in fibroblasts treated with hyperthermia or photodynamic therapy.
        Br J Cancer. 1997; 76: 719-724
        • Frank S.
        • Oliver L.
        • Lebreton-De Coster C.
        • et al.
        Infrared radiation affects the mitochondrial pathway of apoptosis in human fibroblasts.
        J Invest Dermatol. 2004; 123: 823-831
        • Hirano S.
        • Shelden E.A.
        • Gilmont R.R.
        HSP27 regulates fibroblast adhesion, motility, and matrix contraction.
        Cell Stress Chaperones. 2004; 9: 29-37
        • Farber J.L.
        • Rubin E.
        Lippicott Williams & Wilkins, 1998
        • Paul M.
        Three-dimensional radiofrequency tissue tightening: a proposed mechanism and applications for body contouring.
        Aesthetic Plast Surg. 2011; 35: 87-95
      3. Mehta-Ambalal Neocollagenesis and neoelastinogenesis: from the laboratory to the clinic.
        J Cutan Aesthet Surg. 2016; 9: 145-151
        • Greenhalgh D.G.
        • September
        The role of apoptosis in wound healing.
        Int J Biochem Cell Biol. 1998; 30: 1019-1030
      4. Wound healing: methods and protocols.
        in: DiPietro L.A. Burns A.L. Methods in molecular medicine. Humana Press, Totowa, N.J.2003
        • Mirastschijski U.
        • Haaksma C.J.
        • Tomasek J.J.
        • et al.
        Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds.
        Exp Cell Res. 2004; 299: 465-475
        • Hinz B.
        • April
        Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission.
        Eur J Cell Biol. 2006; 85: 175-181
        • Deodhar A.K.
        • Rana R.E.
        Surgical physiology of wound healing: a review.
        J Postgrad Med. 1997; 43: 52-56